KRpep-2d
| Supplier | Creative Peptides |
|---|---|
| Product # | R1941 |
| Pricing | Inquire |
| MolecularFormula | C108H182N44O25S2 |
| MolecularWeight | 2561.01 |
| Storage | Store at -20°C |
| Explanation | KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM. |
| Activity | Inhibitor |
| BiologicalActivity | KRpep-2d binds to K-Ras（G12D）with a Kd of 8.9 nM and approximately 6-fold selectivity over WT K-Ras, leading to an extended dissociation half-life. KRpep-2d significantly suppresses ERK-phosphorylation, downstream of K-Ras(G12D), along with A427 cancer cell proliferation at 30 μM peptide concentration. |
| Reference | 1 Satoshi Sogabe, et al. ACS Med Chem Lett. 2017, 8:732−736. |