LDN-193189 2HCl
LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S7507 |
| Sku # | S7507-5mg |
| Pricing | 5mg, $157.00 |
Citations for this product:
-
bioRxiv - Pharmacology and Toxicology 2023Quote: ... The two small molecule inhibitors LDN193189 (0.1 μM, S7507, Selleck Chemicals) and SB431542 (10 μM ...