AMG-1694
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12614 |
| CAS # | 1361217-07-3 |
| Pricing | inquire |
| Biological Activity | AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. |
| MWt | 533.63 |
| Formula | C₂₃H₃₀F₃N₃O₄S₂ |