KYL acetate

KYL is a selective and potent EphA4 receptor tyrosine kinase antagonist with a Kd value of 0.8 μM. It inhibits EphA4-EphrinA5 interactions with an IC50 value of 6.34 μM. It prevents AβO induced dendritic spine loss and synaptic damage. It also prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. It shows a long half-life in cell culture media. It has a neuroprotective effect.

• Supplier: BOC Sciences
• Product #: BAT-016270
• Molecular Weight: 1525.78
• Molecular Formula: C74H108N14O17.C2H4O2
• Canonical SMILES: O=C(O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1N(C(=O)C(NC(=O)C(NC(=O)C2N(C(=O)C(NC(=O)C(NC(=O)C(N)CCCCN)CC3=CC=C(O)C=C3)CC(C)C)CCC2)CC4=CC=C(O)C=C4)CC5=CNC=6C=CC=CC65)CCC1)C(C)C)CC(C)C)CO)CO)CC(C)C.CC(=O)O