EN6
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-128892-1 mg |
| CAS # | 1808714-73-9 |
| Pricing | 1 mg, USD $50.0 |
| Biological Activity | EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1]. |
| Purity | 99.58% |
| MWt | 368.34 |
| Formula | C₁₉H₁₄F₂N₄O₂ |