C16
C16 is an inhibitor of RNA-activated protein kinase (PKR) (IC50 = 210 nM). It is an imidazolo-oxindole derivative that binds to ATP-binding site of PKR and rescues PKR-dependent translation block in vitro. C16 has neuroprotective activity against cell damage in human neuroblastoma cells and neuroinflammation in acute excitotoxic rat model.
| Supplier | BOC Sciences |
|---|---|
| Product # | 608512-97-6 |
| Pricing | Inquire |
| Cas | 608512-97-6 |
| Molecular Weight | 268.29 |
| Molecular Formula | C13H8N4OS |
| Canonical SMILES | C1=CC2=C(C3=C1NC(=O)C3=CC4=CN=CN4)SC=N2 |