Human Anti-p40 Recombinant Antibody (clone Usekinumab); Fab Fragment
A fully human monoclonal antibody (p40 mAb) directed against human IL-12/23p40 has been shown to be a potent neutralizer of IL-12 and IL-23 function. It has been shown that the p40 mAb binds to the p40 subunit and blocks the binding of both cytokines to their receptors. Because the p40 subunit is shared between IL-12 and IL-23, the detailed interactions between IL-12 and the p40 mAb define an important common neutralizing epitope, which may in turn shed some light on the cytokine-receptor interactions.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-M0535-YC-F(E) |
| Pricing | Inquiry |
| Host | Human |
| Target | p40 |
| Species Reactivity | Human |
| Type | Human Fab |
| Applications | ELISA |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |