Deguelin
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13425-5 mg |
| CAS # | 522-17-8 |
| Pricing | 5 mg, USD $54.0 |
| Synonyms | (-)-Deguelin; (-)-cis-Deguelin |
| MWt | 394.42 |
| Formula | C₂₃H₂₂O₆ |
| Biological Activity | Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. |
| Purity | ≥98.0% |