AF12198
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-P1110-1 mg |
| CAS # | 185413-30-3 |
| Pricing | 1 mg, USD $120.0 |
| Biological Activity | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1]. |
| Purity | 99.61% |
| MWt | 1895.12 |
| Formula | C₉₆H₁₂₃N₁₉O₂₂ |