MD-224
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-114312-10 mg |
| CAS # | 2136247-12-4 |
| Pricing | 10 mg, USD $350.0 |
| Biological Activity | MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent[1]. |
| Purity | 99.74% |
| MWt | 889.8 |
| Formula | C₄₈H₄₃Cl₂FN₆O₆ |