GNE-987
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-129937A-5 mg |
| Pricing | 5 mg, USD $1350.0 |
| Biological Activity | GNE-987 is a highly active chimeric BET degrader. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC)[1]. |
| Purity | 98.90% |
| MWt | 1096.31 |
| Formula | C₅₆H₆₇F₂N₉O₈S₂ |